MICHALSKI Nicolas
2019 Institut de l'Audition
Project status: active
The “Plasticity of central auditory circuits” team headed by Nicolas Michalski focuses on four priorities:
- Making an assessment of the genetic forms of hearing loss (traditionally peripheral) where there are hidden deficiencies in the central auditory system.
- Decrypting the role of genes involved in the development and functioning of the central auditory system.
- Determining which hearing functions are affected by deficiencies in these genes.
- Finally, determining, with the help of the Centre for Research and Innovation in Human Audiology (CERIAH), whether the same deficiencies observed in mice are present in patients.
2016 Early Career Scientific Prize
Project status: closed
Nicolas Michalski is a neuroscience researcher at the Institut Pasteur, where he is part of the team led by Christine Petit in the Genetics and Physiology of Hearing Laboratory[M1]. His work focuses on how the ears and the brain decipher speech, and in particular the mechanism by which sound waves are transmitted in the cells of the inner ear, and the interaction between these cells and brain cells. Through his research, Nicolas is aiming to understand the causes of hearing disorders and the molecules involved.
Nicolas has been involved in science from his earliest years, being intrigued by the “body machine” and how it works. During his studies, Nicolas Michalski met Prof. Christine Petit, who introduced him to genetics and in particular the auditory system. This collaboration has reinforced his interest in the hearing sciences, which he sees as a promising field.
Nicolas works alongside professionals from different fields, sharing discoveries, knowledge and enthusiasm with them to give his projects the right technological and human resources to address hearing issues. When he started in hearing science some 15 years ago, he never thought that research and therapy would evolve as much as they have. In the coming years, he would like to explore issues related to language and speech comprehension. The opening of the new Hearing Institute will provide a springboard for his research.
The Fondation Pour l’Audition Emerging Career Scientific Prize is a true mark of recognition and an unexpected honor.
Doctor Nicolas Michalski
Investigator
Genetics & Physiology of Hearing Lab at Institut Pasteur, Paris, France
Related scientific publication(s) :
- Baptiste Libé-Philippot, Vincent Michel, Jacques Boutet de Monvel, Sébastien Le Gal, Typhaine Dupont, Paul Avan , Christine Métin , Nicolas Michalski, Christine Petit. Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7765-7774. doi: 10.1073/pnas.1703408114. Epub 2017 Jul 13.
- Nicolas Michalski, Juan D Goutman, Sarah Marie Auclair, Jacques Boutet de Monvel, Margot Tertrais, Alice Emptoz, Alexandre Parrin, Sylvie Nouaille, Marc Guillon, Martin Sachse, Danica Ciric, Amel Bahloul, Jean-Pierre Hardelin , Roger Bryan Sutton, Paul Avan, Shyam S Krishnakumar, James E Rothman, Didier Dulon , Saaid Safieddine, Christine Petit. Otoferlin acts as a Ca(2+) sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses. Elife. 2017 Nov 7;6:e31013. doi: 10.7554/eLife.31013.
- Nicolas Michalski, Christine Petit. Genes Involved in the Development and Physiology of Both the Peripheral and Central Auditory Systems. Annu Rev Neurosci. 2019 Jul 8;42:67-86. doi: 10.1146/annurev-neuro-070918-050428. Epub 2019 Jan 30.
- Postal O, Dupont T, Bakay W, Dominique N, Petit C, Michalski N, Gourévitch B. Spontaneous Mouse Behavior in Presence of Dissonance and Acoustic Roughness. Front Behav Neurosci. 2020 Oct 8.
- Christoph Kirst, Sophie Skriabine , Alba Vieites-Prado, Thomas Topilko , Paul Bertin, Gaspard Gerschenfeld, Florine Verny, Piotr Topilko , Nicolas Michalski, Marc Tessier-Lavigne, Nicolas Renier. Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature. Cell . 2020 Feb 20;180(4):780-795.e25. doi: 10.1016/j.cell.2020.01.028. Epub 2020 Feb 13.
- Nicolas Michalski, Christine Petit. Central auditory deficits associated with genetic forms of peripheral deafness. Hum Genet. 2022 Apr;141(3-4):335-345. doi: 10.1007/s00439-021-02339-3. Epub 2021 Aug 25.
- Florian Occelli, Florian Hasselmann, Jérôme Bourien, Jean-Luc Puel, Nathalie Desvignes, Bernadette Wiszniowski, Jean-Marc Edeline, Boris Gourévitch. Temporal Alterations to Central Auditory Processing without Synaptopathy after Lifetime Exposure to Environmental Noise. Cereb Cortex. 2022 Apr 5;32(8):1737-1754.doi: 10.1093/cercor/bhab310.
- Olivier Postal, Warren Bakay, Typhaine Dupont, Alexa Buck, Élodie Daoud, Christine Petit, Nicolas Michalski , Boris Gourévitch. Characterizing subcutaneous cortical auditory evoked potentials in mice. Hear Res. 2022 Jul 3;422:108566. doi: 10.1016/j.heares.2022.108566. Online ahead of print.
[M1]https://research.pasteur.fr/en/team/genetics-physiology-of-hearing/