DiGregorio David

Project status: active

Cerebellar lesions produce major deficits in temporal processing for auditory perception. The cerebellum is a processing apparatus capable of learning precise temporal details on sensory stimuli, which are used to refine motor and cognitive behavior.

Dr. DiGregorio and his team are investigating whether rapid changes to the timescale of the strength of communication between neurons at the entrance of the cerebellum are essential for processing sound components.

Based on mathematical, experimental and genetic models, as well as physiological experiments, Dr. DiGregorio aims to predict how the cerebellum represents/translates/analyzes acoustic information.

Another objective of this project is to identify new cell mechanisms essential to perceiving subtle sound details in a brain region and collect basic information on how neural circuits contribute to the perception of acoustic stimuli.

The analyses proposed by Dr. DiGregorio will lead to new therapeutic targets for hearing disorders and an improved understanding of hearing impairment in autistic and schizophrenic patients.

Doctor David DiGregorio
Researcher-Director of Neuroscience Department
Institut Pasteur, Paris, France