AVAN Paul
Project status: active
Directed by Professor Paul Avan, the Center for Research and Innovation in Human Audiology (CERIAH) at the Hearing Institute is an Institut Pasteur-hosted platform (due to open in March 2021) focusing on developing research protocols involving humans (not including clinical trials for drugs).
Advances in auditory neuroscience have led to the discovery of a range of hearing impairments: some require sound amplification, some require an increase in the contrast between loud and soft sounds, while others require a reduction in noise, etc. Aural rehabilitation devices are available but are only effective if they are adjusted to the specific needs of the patient.
CERIAH aims to deepen our understanding of hearing complaints to arrive at personalized medicine.
Professeur Paul Avan
Director of CERIAH
Institut de l’Audition, Paris, France
Related scientific publication(s):
- Defourny J, Aghaie A, Perfettini I, Avan P, Delmaghani S, Petit C. Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8010-8017. doi: 10.1073/pnas.1821844116. Epub 2019 Apr 1.
- Avan P, Le Gal S, Michel V, Dupont T, Hardelin JP, Petit C, Verpy E. Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25948-25957. doi: 10.1073/pnas.1902781116. Epub 2019 Nov 27.
- Boucher S, Wong Jun Tai F, Delmaghani S, Lelli A, Singh-Estivalet A, Dupont T, Niasme-Grare M, Michel V, Wolff N, Bahloul A, Bouyacoub Y, Bouccara D, Fraysse B, Deguine O, Collet L, Thai-Van H, Ionescu E, Kemeny JL, Giraudet F, Lavieille JP, Devèze A, Roudevitch-Pujol AL, Vincent C, Renard C, Franco-Vidal V, Thibult-Apt C, Darrouzet V, Bizaguet E, Coez A, Aschard H, Michalski N, Lefevre GM, Aubois A, Avan P, Bonnet C, Petit C. Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31278-31289. doi: 10.1073/pnas.2010782117. Epub 2020 Nov 23.